One of the biological pathways by which an amine is converted to a ketone involves two steps:
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One of the biological pathways by which an amine is converted to a ketone involves two steps: (1) oxidation of the amine by NAD+ to give an imine, and (2) hydrolysis of the imine to give a ketone plus ammonia. Glutamate, for instance, is converted by this process into a-ketoglutarate. Show the structure of the imine intermediate, and propose mechanisms for both steps.
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H. NHз NAD* Imine NH3 H20 co2 CO2 a-Ketoglutarate Glutamate
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