The Michaelis-Menten model for enzyme kinetics relates the rate y of an enzymatic reaction, to the concentration
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The Michaelis-Menten model for enzyme kinetics relates the rate y of an enzymatic reaction, to the concentration x of a substrate, as follows:
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Bix B2 + x' where ßi, i = 1,2, are positive parameters. y = 1. Show that the model can be expressed as a linear relation between the values 1/y and 1/x. 2. Use this expression to find an estimate 3 of the parameter vector ß using linear least squares, based on m measurements (xi, Yi), i= 1,..., m. 3. The above approach has been found to be quite sensitive to errors in input data. Can you experimentally confirm this opinion?
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1 Expressing the MichaelisMenten Model as a Linear Relation The MichaelisMenten model is given by th...View the full answer
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Related Book For
Optimization Models
ISBN: 9781107050877
1st Edition
Authors: Giuseppe C. Calafiore, Laurent El Ghaoui
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