Peritoneal dialysis is an alternative method of dialysis in which solute exchange occurs across the peritoneal...
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Peritoneal dialysis is an alternative method of dialysis in which solute exchange occurs across the peritoneal membrane that lines the abdominal cavity. This approach avoids connecting a patient to an external hemodialyzer several times per week for 3-4 hours per dialysis. In peritoneal dialysis, a volume Vp of a glucose solution at the same salt concentration as peritoneal fluid is injected into the peritoneal cavity through an indwelling catheter. After 5 hours, the fluid volume Vp is withdrawn from the peritoneum and replaced with an equal volume of fresh fluid (see figure). Ko, overall mass transfer coefficient Am membrane area Patient – remaining body volume Peritoneal cavity Vo Co V8, distribution volume CB, solute concentration Peritoneal membrane 1) Based on following data obtained for a 5-hr peritoneal dialysis session, determine the concentration of urea and vitamin B12 at the end of the exchange period as a fraction of the concentration in the body. Please comment based on a clinical point of view- specifically, what should a doctor suggest the dialysis patient do based on your answers? Data: Vp = 2 L; Va = 40 L; KAm = 21 cm' min (Urea) and K.Am = 5 cm' min" (Vitamin B12). Peritoneal dialysis is an alternative method of dialysis in which solute exchange occurs across the peritoneal membrane that lines the abdominal cavity. This approach avoids connecting a patient to an external hemodialyzer several times per week for 3-4 hours per dialysis. In peritoneal dialysis, a volume Vp of a glucose solution at the same salt concentration as peritoneal fluid is injected into the peritoneal cavity through an indwelling catheter. After 5 hours, the fluid volume Vp is withdrawn from the peritoneum and replaced with an equal volume of fresh fluid (see figure). Ko, overall mass transfer coefficient Am membrane area Patient – remaining body volume Peritoneal cavity Vo Co V8, distribution volume CB, solute concentration Peritoneal membrane 1) Based on following data obtained for a 5-hr peritoneal dialysis session, determine the concentration of urea and vitamin B12 at the end of the exchange period as a fraction of the concentration in the body. Please comment based on a clinical point of view- specifically, what should a doctor suggest the dialysis patient do based on your answers? Data: Vp = 2 L; Va = 40 L; KAm = 21 cm' min (Urea) and K.Am = 5 cm' min" (Vitamin B12).
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