Many drugs function by interfering with metabolic pathways. The anticancer drug methotrexate, for instance, inhibits the dihydrofolate

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Many drugs function by interfering with metabolic pathways. The anticancer drug methotrexate, for instance, inhibits the dihydrofolate reductase enzyme that catalyzes the following reactions:image

What cofactor is likely to be involved in these reductions? Propose a mechanism.

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