A study was conducted to compare two anesthetic drugs for use in minor surgery using 45 men who were similar in age and physical condition. The two drugs were applied on the right and left ankles of each patient, and after a fixed period of time, the doctor recorded whether or not the ankle remained anesthetized. Data from the 45 patients are recorded below:

a. Is there significant evidence of a difference in the effectiveness of the two drugs. Use a = .05.
b. Place a 95% confidence on the difference in the effectiveness of the two drugs.

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Drug 2 Response Remains Anesthetized Not Anesthetized Drug 1 Response Remains Anesthetized Not Anesthetized 12 10 14