DNA precursor imbalances are mutagenic. For example, if dGTP accumulates, it can compete with dATP for incorporation

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DNA precursor imbalances are mutagenic. For example, if dGTP accumulates, it can compete with dATP for incorporation opposite dTMP in the template, leading to a transition mutation. Investigators have shown that a modest balanced increase in all four dNTPs, three- or fourfold, stimulated mutagenesis out of proportion to the dNTP pool change. Describe a mechanism by which this could occur.
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Biochemistry Concepts and Connections

ISBN: 978-0321839923

1st edition

Authors: Dean R. Appling, Spencer J. Anthony Cahill, Christopher K. Mathews

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