Figure 4.99 shows the plasma levels of canrenone in a healthy volunteer after a single oral dose

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Figure 4.99 shows the plasma levels of canrenone in a healthy volunteer after a single oral dose of spironolactone given on a fasting stomach and together with a standardized breakfast. Discuss the effect of food on peak concentration and time to reach peak concentration. Is the effect of the food strongest during the first 8 hours, or after 8 hours?

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Applied Calculus

ISBN: 9781119275565

6th Edition

Authors: Deborah Hughes Hallett, Patti Frazer Lock, Andrew M. Gleason, Daniel E. Flath, Sheldon P. Gordon, David O. Lomen, David Lovelock, William G. McCallum, Brad G. Osgood, Andrew Pasquale

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Question Posted: Apr 15, 2023 02:00 AM

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Figure 4.99 shows the plasma levels of canrenone in a healthy volunteer after a single oral dose

Question:

concentration of canrenone (ng/ml) 400 300 200 100 1 Fasting stomach 2468 Standardized breakfast Figure 4.99 24 1 (hours)

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From the graph in Figure 499 we can see that the peak concentration of canrenone is higher when it i...View the full answer

Applied Calculus

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