A study by Ikeda et al. (A-49) was designed to determine the dose of ipratropium bromide aerosol that improves exercise performance using progressive cycle ergometry in patients with stable chronic obstructive pulmonary disease. The mean age of the 20 male subjects was 69.2 years with a standard deviation of 4.6 years. Among the data collected were the following maximum ventilation VEmax;L=min values at maximum achieved exercise for different ipratropium bromide dosage levels ð Þ mg :

Placebo 40 80 160 240 26 24 23 25 28 38 39 43 43 37 49 46 54 57 52 37 39 39 38 38 34 33 37 37 41 42 38 44 44 42 23 26 28 27 22 38 41 44 37 40 37 37 36 38 39 33 35 34 38 36 40 37 40 46 40 52 58 48 58 63 45 48 47 51 38 24 30 23 27 30 41 37 39 46 42 56 54 51 58 58 35 51 49 51 46 28 41 37 33 38 28 34 34 35 35 38 40 43 39 45 Source: Data provided courtesy of Dr. Akihiko Ikeda.