Estrogen and endometrial cancer. Table 18.25 contains data from a matched case-control study on conjugated estrogen use and endometrial cancer.

TABLE 18.25 Estrogen use and endometrial cancer, case–control, matched pairs.

Data from Antunes, C. M., Strolley, P. D., Rosenshein, N. B., Davies, J. L., Tonascia, J. A., Brown, C., et al. (1979). Endometrial cancer and estrogen use.

Report of a large case-control study. New England Journal of Medicine, 300(1), 9–13 as reported on p. 137 of Abramson, J. H., & Gahlinger, P. M.

(2001). Computer Programs for Epidemiologic Analyses: PEPI v. 4.0. Salt Lake City, UT: Sagebrush Press.

(a) Calculate the odds ratio for estrogen exposure and endometrial cancer. Interpret this result

(b) Calculate a 95% confidence interval for the OR. Interpret this result.

(c) Test the hypothesis.