Garland et al. (A-27) conducted a series of experiments to delineate the complex maternal-fetal pharmacokinetics and the effects of zidovudine (AZT) in the chronically instrumented maternal and fetal baboon (Papio species) during both steady-state intravenous infusion and oral bolus dosage regimens. Among the data collected were the following measurements on dosage

(mg/kg/h) and steady-state maternal plasma AZT concentration (ng/ml):

AZT AZT Dosage Concentration Dosage Concentration 2.5 832 2.0 771 2.5 672 1.8 757 2.5 904 0.9 213 2.5 554 0.6 394 2.5 996 0.9 391 1.9 878 1.3 430 2.1 815 1.1 440 1.9 805 1.4 352 AZT AZT Dosage Concentration Dosage Concentration 1.9 592 1.1 337 0.9 391 0.8 181 1.5 710 0.7 174 1.4 591 1.0 470 1.4 660 1.1 426 1.5 694 0.8 170 1.8 668 1.0 360 1.8 601 0.9 320 Source: Dr. Marianne Garland. Used with permission.