Ichinose et al. (A-20) studied the involvement of endogenous tachykinins in exercise-induced airway narrowing in patients with asthma by means of a selective neurokinin 1-receptor antagonist, FK-888. Nine subjects (eight male, one female) ages 18 to 43 years with at least a 40 percent fall in the specific airway conductance participated in the study. The following are the oxygen consumption

(ml/min) data for the subjects at rest and during exercise while under treatment with a placebo and FK-888:

Placebo FK-888 At Rest Exercise At Rest Exercise 303 2578 255 2406 288 2452 348 2214 285 2768 383 3134 280 2356 328 2536 295 2112 321 1942 270 2716 234 2652 274 2614 387 2824 185 1524 198 1448 364 2538 312 2454