In the article “Assessment of the DRCR Retina Network Approach to Management With Initial Observation for Eyes With Center-Involved Diabetic Macular Edema and Good Visual Acuity: A Secondary Analysis of a Randomized Clinical Trial”

published in JAMA Opthalmology (Glassman, 2020), the authors reported the summary statistics in Table 5.17 on the change in OCT central subfield thickness from a baseline measurement for individualswho did not receive aflibercept (control) and those who did receive aflibrocept. Use the summary statistics in Table 5.17 to answer the following

(a) Estimate the difference between the mean change in OCT central subfield thickness for the aflibercept and control group.

(b) Compute the estimated standard error of the difference of the sample means.

(c) Compute the bound on the error of estimation associated with the difference of the sample means.