In the article “Limited family structure and BRCA gene mutation status in single cases of breast cancer” published in JAMA (Weitzel et al., 2007), the authors reported the 2 × 2 contingency table given in Table 7.33 for investigating the association between family structure and whether or not an individual was a BRCA carrier. Use the contingency table in Table 7.33 to answer the following questions.

(a) Compute the odds ratio.

(b) Does the odds ratio in part

(a) support the claim that family structure is independent of BRCA carrier status? Explain.

(c) Does the data in Table 7.33 support the use of a chi-squared test of independence?

(d) Test the hypothesis that family structure is independent of carrier status at the

???? = 0.05 level.