Johansson et al. (A-57) compared the effects of short-term treatments with growth hormone (GH) and insulin-like growth factor I (IGF-I) on biochemical markers of bone metabolism in men with idiopathic osteoporosis. Subjects ranged in age from 32 to 57 years. Among the data collected were the following serum concentrations of IGF binding protein-3 at 0 and 7 days after first injection and 1, 4, 8, and 12 weeks after last injection with GH and IGF-I.