Seghaye et al. (A-31) analyzed the influence of low-dose aprotinin on complement activation, leukocyte stimulation, cytokine production, and the acute-phase response in children undergoing cardiac operations. Inclusion criterion for the study was a noncyanotic congenital cardiac defect requiring a relatively simple primary surgical procedure associated with a low postoperative risk.

Among the data collected were the following measurements on interleukin-6 (IL-6) and C-reactive protein (CRP) obtained 4 and 24 hours postoperatively, respectively:

IL-6 CRP IL-6 CRP IL-6 CRP 122 32 467 53 215 50 203 39 421 29 415 41 458 63 421 44 66 12 78 7 227 24 58 14 239 62 265 31 213 9 165 22 97 12 Source: Dr. Marie-Christine Seghaye. Used with permission.