The objective of a study by Witteman et al. (A-26) was to investigate skin reactivity with purified major allergens and to assess the relation with serum levels of immunoglobulin E (IgE) antibodies and to determine which additional factors contribute to the skin test result. Subjects consisted of patients with allergic rhinitis, allergic asthma, or both, who were seen in a European medical center. As part of their study, the researchers collected, from 23 subjects, the following measurements on specific IgE (IU/ml) and skin test (ng/ml) in the presence of Lol p 5, a purified allergen from grass pollen. We wish to know the nature and strength of the relationship between the two variables. (Note: The authors converted the measurements to natural logarithms before investigating this relationship.)

IgE Skin Test 24.87 .055 12.90 .041034 9.87 .050909 8.74 .046 6.88 .039032 5.90 .050909 4.85 .042142 3.53 .055 2.25 4.333333 2.14 .55 1.94 .050909 1.29 .446153

.94 .4

.91 .475

.55 4.461538 .30 4.103448 .14 7.428571 .11 4.461538 .10 6.625 .10 49.13043 .10 36.47058 .10 52.85714 .10 47.5 Source: Data provided courtesy of Dr. Jaring S. van der Zee.