The objective of a study by Yamashita et al. (A-45) was to investigate whether pentoxifylline administered in the flush solution or during reperfusion would reduce ischemia-reperfusion lung injury in preserved canine lung allografts. Three groups of animals were studied. Pentoxifylline was not administered to animals in group 1 (C), was administered only during the reperfusion period (P)

to animals in group 2, and was administered only in the flush solution to animals in group 3 (F). A total of 14 left lung allotransplantations were performed. The following are the aortic pressure readings for each animal during the 6-hour assessment period:

Group 0

min 60 min 120 min 180 min 240 min 300 min 360 min C 85.0 100.0 120.0 80.0 72.0 75.0 

C 85.0 82.0 80.0 80.0 85.0 80.0 80.0 C 100.0 75.0 85.0 98.0 85.0 80.0 82.0 C 57.0 57.0 57.0 30.0 

C 57.0 75.0 52.0 56.0 65.0 95.0 75.0 P 112.0 67.0 73.0 90.0 71.0 70.0 66.0 P 92.0 70.0 90.0 80.0 75.0 80.0 2



P 105.0 62.0 73.0 75.0 70.0 55.0 50.0 P 80.0 73.0 50.0 35.0 

F 70.0 95.0 105.0 115.0 110.0 105.0 100.0 F 60.0 63.0 140.0 135.0 125.0 130.0 120.0 F 67.0 65.0 75.0 75.0 80.0 80.0 80.0 F 115.0 107.0 90.0 103.0 110.0 112.0 95.0 F 90.0 99.0 102.0 110.0 117.0 118.0 103.0

 Missing observation.

Source: Data provided courtesy of Dr. Motohiro Yamashita.