The purpose of a study by Kim et al. (A-25) was to investigate the serial changes in Lp

(a) lipoprotein levels with the loss of female sex hormones by surgical menopause and with estrogen replacement therapy in the same women. Subjects were 44 premenopausal women who underwent a transabdominal hysterectomy (TAH). Thirty-one of the women had a TAH and unilateral salpingooophorectomy (USO), and 13 had a TAH and bilateral salpingo-oophorectomy (BSO). The women ranged in age from 30 to 53 years. Subjects in the BSO group received .625 mg of conjugated equine estrogen daily 2 months after the operation. The following were the subjects’ total cholesterol levels before (TC0), 2 months after (TC2), and 4 months after (TC4) the surgical procedure and hormone replacement therapy.

USO USO Subject TC0 TC2 TC4 Subject TC0 TC2 TC4 1 202 203 196 25 134 131 135 2 204 183 203 26 163 190 185 3 206 199 192 27 196 183 192 4 166 180 176 28 181 194 208 5 150 171 154 29 160 162 181 6 137 134 129 30 188 200 181 7 164 168 171 31 172 188 189 8 207 249 223 9 126 121 140 10 131 141 167 BSO 11 133 159 149 Subject TC0 TC2 TC4 12 142 152 140 32 224 218 239 13 225 193 180 33 202 196 231 14 158 182 179 34 181 182 208 15 184 177 182 35 191 230 208 16 223 244 234 36 248 284 279 17 154 178 187 37 224 228 199 18 176 137 162 38 229 318 272 19 205 253 288 39 147 199 194 20 167 156 136 40 248 258 302 21 164 176 191 41 160 218 229 22 177 168 185 42 175 187 166 23 140 175 167 43 262 260 247 24 167 186 195 44 189 199 181