Treating Chronic Fatigue Syndrome Patients with chronic fatigue syndrome were tested, and then retested after being treated with fludrocortisone. A standard scale from -7 to +7 is used to measure fatigue before and after the treatment. The changes are summarized with these statistics: n = 21, x = 4.00, s = 2.17 (based on data from “The Relationship Between Neurally Mediated Hypotension and the Chronic Fatigue Syndrome,” by Bou-Holaigah, Rowe, Kan, and Calkins, Journal of the American Medical Association, Vol. 274, No. 12). The changes were computed in a way that makes positive values represent improvements. Use a 0.01 significance level to test the claim that the mean change is positive. Does the treatment appear to be effective?