Tsau et al. (A-20) studied urinary epidermal growth factor (EGF) excretion in normal children and those with

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Tsau et al. (A-20) studied urinary epidermal growth factor (EGF) excretion in normal children and those with acute renal failure (ARF). Random urine samples followed by 24-hour urine collection were obtained from 25 children. Subjects ranged in age from 1 month to 15 years. Urinary EGF excretion was expressed as a ratio of urinary EGF to urinary creatinine concentration (EGF/Cr).

The authors conclude from their research results that it is reasonable to use random urine tests for monitoring EGF excretion. Following are the random (spot) and 24-hour urinary EGF/Cr concentrations

(pmol/mmol) for the 25 subjects:

24-h Urine Spot Urine 24-h Urine Spot Urine Subject EGF/Cr (x) EGF/Cr (y) Subject EGF/Cr (x) EGF/Cr (y)

1 772 720 14 254 333 2 223 271 15a 93 84 3 494 314 16 303 512 4 432 350 17 408 277 5a 79 79 18 711 443 6a 155 118 19 209 309 7 305 387 20 131 280 8 318 432 21 165 189 9a 174 97 22 151 101 10 1318 1309 23 165 221 11 482 406 24 125 228 12 436 426 25 232 157 13 527 595

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