Uryu et al. (A-23) studied the effect of three different doses of troglitazone mM on

Uryu et al. (A-23) studied the effect of three different doses of troglitazone ð Þ mM on neuro cell death.

Cell death caused by stroke partially results from the accumulation of high concentrations of glutamate. The researchers wanted to determine if different doses of troglitazone (1.3, 4.5, and 13:5mM) and different ion forms ð Þ and þ of LY294002, a PI3-kinase inhibitor, would give different levels of neuroprotection. Four rats were studied at each dose and ion level, and the measured variable is the percent of cell death as compared to glutamate. Therefore, a higher value implies less neuroprotection. The results are displayed in the table below.

Percent Compared to Glutamate LY294002 vs þ LY294002 Troglitazone Dose (mM)

73.61 Negative 1.3 130.69 Negative 1.3 118.01 Negative 1.3 140.20 Negative 1.3 97.11 Positive 1.3 114.26 Positive 1.3 120.26 Positive 1.3 92.39 Positive 1.3 26.95 Negative 4.5 53.23 Negative 4.5 59.57 Negative 4.5 53.23 Negative 4.5 28.51 Positive 4.5 30.65 Positive 4.5 44.37 Positive 4.5 36.23 Positive 4.5 8:83 Negative 13.5 25.14 Negative 13.5 20.16 Negative 13.5 34.65 Negative 13.5 35:80 Positive 13.5 7:93 Positive 13.5 19:08 Positive 13.5 5.36 Positive 13.5 Source: Data provided courtesy of Shigeko Uryu.