3.6 A study considered the effect of prednisolone on severe hypercalcemia in women with metastatic breast cancer (B. Kristensen et al., J. Intern. Med. 232: 237-245, 1992). Of 30 patients, 15 were randomly selected to receive prednisolone. The other 15 formed a control group. Normalization in their level of serum-ionized calcium was achieved by 7 of the treated patients and none of the control group. Obtain a 95% confidence interval for the odds ratio using

(a) the Wald interval and

(b) the profile likelihood. In each case, note the effect of the zero cell count.