Several different formulas have been proposed for determining the appropriate dose of a drug for a child in terms of the adult dosage. Suppose that A milligrams (mg) is the adult dose of a certain drug and C is the appropriate dosage for a child of age N years. Then Cowling’s rule says that

while Friend’s rule says that

Exercises 46 through 48 require these formulas.

If an adult dose of ibuprofen is 300 mg, what dose does Cowling’s rule suggest for an 11-yearold child? What dose does Friend’s rule suggest for the same child?

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1 - (N₂+¹) ₁ A 24 C =