Isophthalic acid (IPA, formula HOOC-C6H4-COOH) is made by oxidation of m-xylene with air. The reaction is carried out in acetic acid solvent at about 200 °C using a cobalt-manganese catalyst promoted by bromine. Acetic acid is boiled off, condensed and returned to the reactor to remove the heat of reaction, and the reactor pressure is set to allow an adequate evaporation rate of acetic acid. IPA is not soluble in acetic acid, so the product crystallizes, and a slurry can be removed from the base of the reactor for product recovery. Design and size a reactor system for production of 25,000 metric tons per year of IPA.