Given that we wish to specify the location of an operand in memory, how does indirect addressing

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Given that we wish to specify the location of an operand in memory, how does indirect addressing differ from direct addressing? What are the advantages of indirect addressing, and in what circumstances is it clearly preferable to direct addressing? Are there any disadvantages of using indirect addressing? How is register-indirect addressing different from memory-indirect addressing, and what are the relative advantages and disadvantages of each?

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