A small spherical bead is used as a controlled drug release capsule in the gastrointestinal system (i.e.,
Question:
A small spherical bead is used as a controlled drug release capsule in the gastrointestinal system (i.e., your stomach). In this particular case, a 0.10-cm diameter bead has a uniform initial concentration of 0.20 mmole/L of the drug griseofulvin (species A). The diffusion coefficient of griseofulvin within the bead material is 1.5 × 10-7 cm2/s. Upon release from the bead, the drug is immediately consumed so that the surface concentration is essentially zero.
a. Using the concentration-time charts, determine the time it will take for concentration of the griseofulvin in the center of the bead to reach 10% of its initial value.
b. Using the infinite series analytical solution for cA(r,t), determine the time it will take for concentration of the griseofulvin in the center of the bead to reach 10% of its initial value, and then plot out the concentration profile from r = 0 (center) to r = R (surface). Carry out your calculations on a computer spreadsheet.
Step by Step Answer:
Fundamentals Of Momentum Heat And Mass Transfer
ISBN: 9781118947463
6th Edition
Authors: James Welty, Gregory L. Rorrer, David G. Foster