Assess the statistical significance of the individual risk factors?

Cardiovascular Disease

Sudden death is an important, lethal cardiovascular endpoint. Most previous studies of risk factors for sudden death have focused on men. Looking at this issue for women is important as well. For this purpose, data were used from the Framingham Heart Study [47]. Several potential risk factors, such as age, blood pressure, and cigarette smoking, are of interest and need to be controlled for simultaneously. Therefore, a multiple logistic-regression model was fitted to these data, as shown in Table 13.48.

Table 13.48 Multiple logistic-regression model relating 2-year incidence of sudden death in females without prior CHD (data taken from the Framingham Heart Study) to several risk factors

 

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Regression coefficient, B, se(â, ) Risk factor Constant -15.3 Systolic blood pressure (mm Hg) Framingham relative weight (%) Cholesterol (mg/100 mL) Glucose (mg/100 mL) Cigarette smoking (cigarettes/day) Hematocrit (%) Vital capacity (cL) Age (years) 0.0019 0.0070 -0.0060 0.0100 0.0056 0.0029 0.0066 0.0038 0.0069 0.0199 0.111 0.049 -0.0098 0.0036 0.0686 0.0225