Perform an adjusted analysis comparing breast cancer incidence between the current PMH users vs. the never PMH users, adjusting for confounders that you found in Problem 14.65?

Cancer

The data set in file BREAST.DAT consists of 1200 women in the NHS. The women were ascertained in 1990 and were postmenopausal and free of any cancer as of 1990. The 1200 women were selected in such a way that 200 of the women were current postmenopausal hormone (PMH) users in 1990 and 1000 of the women had never used PMH as of 1990. The objective of the analysis was to relate breast cancer incidence from 1990 to 2000 to PMH use as of 1990. Fifty-three of the women developed breast cancer between 1990 and 2000. PMH use is characterized both by current use/never use in 1990 as well as by duration of use as of 1990. Some current users in 1990 may have duration of use of 0 as of 1990 if they just started use in 1990 or if they used other types of PMH as of 1990 (other than estrogen or estrogen plus progesterone). There are two duration variables according to type of PMH use (duration of estrogen use in months as of 1990 and duration of estrogen plus progesterone use in months as of 1990). Each woman has a date of return of the 1990 questionnaire and a follow-up date = date of diagnosis of breast cancer if a case, or date of the last questionnaire filled out up to 2000 if a control. On the data file we provide the length of followup= follow-up date - date of return of the 1990 questionnaire (variable 18). Thus, the first subject (ID 10013) had a date of return of 1087 = July 1990 = (12 × 90 + 7) and a follow-up date of 1206 = June 2000 = (12 × 100 + 6). In addition, the file contains the values of other breast cancer risk factors as of 1990. A description of the data set is given in BREAST.DOC.

Format for Breast Cancer—postmenopausal hormone file

1. ID

2. Case 1=case, 0=control

3. Age

4. Age at menarche

5. Age at menopause

6. Age at first birth 98=nullip

7. Parity

8. Benign Breast disease (bbd) 1=yes/0=no

9. Family history of breast cancer 1=yes/0=no

10. BMI (kg/m**2)

11. Height (inches)

12. Alcohol use (grams/day)

13. PMH status 2=never user/3=current user

14. Duration of Estrogen use (months)

15. Duration of Estrogen + progesterone use (months)

16. Current Smoker 1=yes/0=no

17. Past smoker 1=yes/0=no

18. Follow-up time (months)