Perform the test in Problem 10.90, and report a two-tailed p-value? Otolaryngology Acute OTM early in infancy

Question:

Perform the test in Problem 10.90, and report a two-tailed p-value?

Otolaryngology

Acute OTM early in infancy may be an important predictor of subsequent morbidity, including psychological and educational difficulties. A study was performed among high-risk infants who had already experienced either a single episode of acute OTM prior to the age of 6 months or two or more episodes before 12 months of life [23].

Children were randomized to one of three treatment groups, (a) amoxicillin (AMX), (b) sulfisoxazole (SUL), or (c) placebo (PLA), and their parents were told to administer the drug daily for a 6-month period (even in the absence of symptoms). If children had an acute OTM episode during the study period, they received the best antibiotic care, regardless of their study-drug group. The results were as shown in Table 10.36.

Table 10.36: Experience with acute OTM in 6 months after entry into the study

% Acute OTM-free Drug group AMX SUL 70 40 47 32 36 41 PLA