Suppose 10% of the women assigned to the alendronate 5-mg group are actually not taking their pills
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Suppose 10% of the women assigned to the alendronate 5-mg group are actually not taking their pills (noncompliers). If noncompliers are assumed to have a similar response as women in the placebo group, what percentage of women complying with the alendronate 5-mg treatment would be expected to have a clinically significant decline?
The change in bone-mineral density of the lumbar spine over a 2-year period among women in the alendronate 5-mg group was +3.5% (a mean increase), with a standard deviation of 4.2%.
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