Suppose the change (mean ± sd ) in intraocular pressure after administration of diflunisal (follow-up – baseline) among 10 patients whose standard therapy was methazolamide and topical glaucoma medications was −1.6 ± 1.5 mm Hg. Assess the statistical significance of the results?

Ophthalmology

The drug diflunisal is used to treat mild to moderate pain due to osteoarthritis (OA) and rheumatoid arthritis (RA). The ocular effects of diflunisal had not been considered until a study was conducted on its effect on intraocular pressure in glaucoma patients who were already receiving maximum therapy for glaucoma [5].