Suppose we have 10 patients who receive lnterleukin- 2 plus vaccine of whom 2 develop arrhythmia and 8 do not. What is the probability that exactly 3 of the 10 patients will get a positive response to treatment?

One issue is that some patients experience side effects and have to discontinue treatment. lt was estimated that 19% of patients receiving lnterleukin-2 plus vaccine developed an arrhythmia (irregular heartbeat) and had to discontinue treatment. Since the side effect was attributable to the vaccine, assume that the patients would continue to take lnterleukin-2 if arrhythmia developed but not the vaccine and that the probability of a positive response to treatment would be the same as group A (i.e., 6%).