A pharmaceutical product is designed to be absorbed in the gastrointestinal tract. The active ingredient is pressed
Question:
A pharmaceutical product is designed to be absorbed in the gastrointestinal tract. The active ingredient is pressed into a tablet with a density of pA = 15 kg/m3 while the remainder of the tablet is composed of inactive ingredients. The partition coefficient is K = 3 X 10–2, and the diffusion coefficient of the active ingredient in the gastrointestinal fluid is DAB = 0.4 X 10–10 m2/s.
(a) Estimate the dosage delivered over a time period of 5 h for a spherical tablet of diameter D = 6 mm.
(b) Estimate the dosage delivered over 5 h for N = 200 small, spherical tablets contained in a gelatin capsule that quickly dissolves after ingestion, releasing the medication. The initial mass of the medication is the same as in part (a).
Step by Step Answer:
Fundamentals Of Heat And Mass Transfer
ISBN: 9780470501979
7th Edition
Authors: Theodore L. Bergman, Adrienne S. Lavine, Frank P. Incropera, David P. DeWitt