Interactions between DNA and metal complexes are the basis for the use of square planar platinum(II)-containing anti-cancer
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Interactions between DNA and metal complexes are the basis for the use of square planar platinum(II)-containing anti-cancer drugs.
(a) Explain how the interaction of right-handed DNA with chiral complexes leads to diastereoisomeric species.
(b) How does the replacement of the two NH3 ligands in cisplatin (see below) by two PhMeCHNH2 ligands affect the chirality of the complex?
(c) The bidentate ligands drawn opposite may be used to prepare analogues of cisplatin. Draw the structures of the complexes formed and indicate all asymmetric centres. For a given ligand, which pairs of complexes are related by being enantiomers or diastereoisomers?
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a Interaction of righthanded DNA with chiral complexes leads to diastereoisomeric species because DNA is a chiral molecule meaning it lacks a plane of ...View the full answer
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