(b) Perform a fixed-effect meta-analysis on the stacked data set, using a method that estimates the...

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(b) Perform a fixed-effect meta-analysis on the ‘stacked’ data set, using a method that

• estimates the effect of treatment as a log odds ratio,

• assumes that the number of deaths in each treatment in each trial follows a binomial distribution and

• does not depend on an approximation based on the normal distribution.

Compare the results with those of the corresponding analysis based on the normal approximation, obtained previously. In what situations would you expect to find poor agreement between the results of the two analyses?

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