A method for negative exponential modeling of survival times relates to the Poisson loglinear model for rates
Question:
A method for negative exponential modeling of survival times relates to the Poisson loglinear model for rates (Aitkin and Clayton 1980). Let T denote the time to some event, with pdf f and cdf F. For subject i, let wi = 1 for death and 0 for censoring, and let t = ∑
i ti and w = ∑
i wi.
a. Explain why the survival-time log-likelihood for n independent observations is10 L(????) = ∑
i wi log[f(ti)] +
∑
i
(1 − wi) log[1 − F(ti)].
Assuming f(t) = ???? exp(−????t), show that ????̂ = w∕t. Conditional on t, explain why w has a Poisson distribution with mean t????. Using the Poisson likelihood, show that ????̂ = w∕t.
b. With ???? replaced by ???? exp(x????) and with ????i = ti???? exp(xi????), show that L simplifies to L(????, ????) = ∑
i wi log ????i −
∑
i ????i −
∑
i wi log ti.
Explain why maximizing L(????, ????) is equivalent to maximizing the likelihood for the Poisson loglinear model log ????i − log ti = log ???? + xi????
with offset log(ti), using “observations” {wi}.
c. When we sum terms in L for subjects having a common value of x, explain why the observed data are the numbers of deaths (∑
i wi) at each setting of x, and the offset is log(∑
i ti) at each setting.
Step by Step Answer:
Foundations Of Linear And Generalized Linear Models
ISBN: 9781118730034
1st Edition
Authors: Alan Agresti