An alternative latent variable model results from early applications of binary response models to toxicology studies (such
Question:
An alternative latent variable model results from early applications of binary response models to toxicology studies (such as Table 5.4) of the effect of dosage of a toxin on whether a subject dies, with an unobserved tolerance distribution. For a randomly selected subject, let xi denote the dosage level and let yi = 1 if the subject dies. Suppose that the subject has a latent tolerance threshold Ti for the dosage, with (yi = 1) equivalent to (Ti ≤ xi
). Let F(t) =
P(T ≤ t).
a. For fixed dosage xi, explain why P(yi = 1 ∣ xi
) = F(xi).
b. Suppose F belongs to the normal parametric family, for some ???? and ????.
Explain why the model has the form
Φ−1(????i) = ????0 + ????1xi and relate ????0 and ????1 to ???? and ????.
Step by Step Answer:
Foundations Of Linear And Generalized Linear Models
ISBN: 9781118730034
1st Edition
Authors: Alan Agresti