Bacteriophage MS2 carries its genetic information in RNA. Its chromosome is analogous to a polygenic molecule of

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Bacteriophage MS2 carries its genetic information in RNA. Its chromosome is analogous to a polygenic molecule of mRNA in organisms that store their genetic information in DNA. The MS2 minichromosome encodes four polypeptides (i.e., it has four genes). One of these four genes encodes the MS2 coat protein, a polypeptide of 129 amino acids long. The entire nucleotide sequence in the RNA of MS2 is known. Codon 112 of the coat protein gene is CUA, which specifies the amino acid leucine. If you were to treat a replicating population of bacteriophage MS2 with the mutagen 5-bromouracil, what amino acid substitutions would you expect to be induced at position 112 of the MS2 coat protein (i.e., Leu → other amino acid)? 

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Principles of Genetics

ISBN: 978-1119142287

7th edition

Authors: D. Peter Snustad, Michael J. Simmons

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