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1. A male patient is being treated for Hodgkin's lymphoma with vincristine. He also takes phenytoin daily in the morning for a seizure disorder.
1. A male patient is being treated for Hodgkin's lymphoma with vincristine. He also takes phenytoin daily in the morning for a seizure disorder. How will these two medications interact? A. Vincristine, when combined with phenytoin, will increase sedation. B. Phenytoin and vincristine are metabolized by CYP3A4, increasing vincristine toxicity. C. Phenytoin administered with vincristine will decrease cytotoxic drug effects. D. Vincristine will increase the patient's risk of having a seizure.
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