1. A mass mA of drug A is introduced as a bolus into the blood stream at time zero. The drug does not enter red blood cells, the plasma is assumed to be well-mixed, and the total plasma volume is VP. The drug leaves the plasma by two mechanisms: (1) elimination by the kidney, with the rate of elimination being proportional to plasma concentration of the blood (or wout= kCA ); and (2) transport into the tissue through the microvascular barrier, which has a permeability P and surface area S. Once the drug passes across the microvascular barrier, it is instantly utilized by the tissue cells, so the tissue concentration of drug A can be assumed to be zero for all time. What is the concentration of A in the plasma as a function of time? 1. A mass mA of drug A is introduced as a bolus into the blood stream at time zero. The drug does not enter red blood cells, the plasma is assumed to be well-mixed, and the total plasma volume is VP. The drug leaves the plasma by two mechanisms: (1) elimination by the kidney, with the rate of elimination being proportional to plasma concentration of the blood (or wout= kCA ); and (2) transport into the tissue through the microvascular barrier, which has a permeability P and surface area S. Once the drug passes across the microvascular barrier, it is instantly utilized by the tissue cells, so the tissue concentration of drug A can be assumed to be zero for all time. What is the concentration of A in the plasma as a function of time