1. Compare the RNA-dependent RNA-polymerase utilized bySARS-CoV-2 and DNA-dependent DNA polymerase as in classic centraldogma. Which has higher fidelity and why? You may use Pubmed tofind additional sources if necessary.

2. What are genomic hotspots? Considering COVID-19 iscaused by a novel virus among humans, what process(es) might theseareas of the genome be critical in enabling?

Areas of the genome that mutate a lot, so it means it isnot an essential part of the virus because it is constantlychanging. The processes that these areas of the genome might becritical in enabling are .

3. What proteins are encoded in the SARS-CoV-2genome? What is the general function of each?