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1. Consider the two sequences GRQTAGL and GTAYDL. Show two optimal global alignments for these sequences using the BLOSUM62 matrix (shown below) and a linear

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1. Consider the two sequences GRQTAGL and GTAYDL. Show two optimal global alignments for these sequences using the BLOSUM62 matrix (shown below) and a linear gap penalty of d --8. Show your Workings R-1 NI-2 0 C0 -3 -3 -3 2 -1 E -1 0 0 0 0 -3 4 ?1-1-2-3-4-1-2-3-4-3 KI-1 11 0-1-3 -2-1-3-2. MI-1-1-2-3-1 0-2-3-2 -1 F1-2-3-3-3-2-3-3-3-1 0 0-3 0 P-1 -2 -2 -1 -3 -1 -1 -2-2-3 -3 -12 -4 1-1 0-1 0 0 0-1-2-2 0-1-2-1 T10-1-0-1-1-1-1-2-2-1-1-1-1-2-1 Y?-2-2-2-3-2-1-2-3-1-1-2-1 1-3-2-2 V 0-3 -3 3 1 -22-33 4 marks 1. Consider the two sequences GRQTAGL and GTAYDL. Show two optimal global alignments for these sequences using the BLOSUM62 matrix (shown below) and a linear gap penalty of d --8. Show your Workings R-1 NI-2 0 C0 -3 -3 -3 2 -1 E -1 0 0 0 0 -3 4 ?1-1-2-3-4-1-2-3-4-3 KI-1 11 0-1-3 -2-1-3-2. MI-1-1-2-3-1 0-2-3-2 -1 F1-2-3-3-3-2-3-3-3-1 0 0-3 0 P-1 -2 -2 -1 -3 -1 -1 -2-2-3 -3 -12 -4 1-1 0-1 0 0 0-1-2-2 0-1-2-1 T10-1-0-1-1-1-1-2-2-1-1-1-1-2-1 Y?-2-2-2-3-2-1-2-3-1-1-2-1 1-3-2-2 V 0-3 -3 3 1 -22-33 4 marks

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