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d21.msu.edu C - O. IS1 - FS23-NEU-301- Intr. Och 5 Bioenergetics: T. M LON-CAPA Puzzle of. Chapter 5 Excitable C. Start Page Star In the following experiment, phosphorylated CREB (pCREB) levels were measured through Fluorescence intensity in cells that came from a brain area called the hippocampus. Here, an increase in intensity indicates an increase in pCREB levels The "---" condition indicates a control condition. The 17BE is a condition where the cells were treated with 17 BE (a form of estrogen that is acting like a neurotransmitter in this example). The gray bars are both treated with, the drug U73122, which acts to inhibit Protein Lipase C (PLC). (* * indicates statistical significance compared to the non-drug 17BE group.) (Boulware et al. 2005) Which of the following conclusions can be made from this set of data? 1500 - U73122 1000 * * PCREB (Fluorescence Intensity) T 500 --- 17BE -- 17BE A) 17BE activates CREB within the hippocampus by binding to metabotropic receptors and activating the CAMP pathway through the Gai subunit B) 17BE activates CREB within the hippocampus by binding to metabotropic receptors and activating the CAMP pathway through the Gas subunit. C) 17BE deactivates CREB within the hippocampus by binding to metabotropic receptors and activating the Phosphatidyl Inositol Biphosphate (PIP2) pathway through the Gaq subunit. O 16 OCT 209m 4 MacBook Pro esc