1. Discuss the validity of the following three statements:

1. A unilateral offer can be revoked at any time before acceptance.

2. A unilateral offer is only accepted once performance of the stipulated task is completed.

3. There is no need to communicate acceptance or revocation of a unilateral offer.

2.I cannot find out why some of the autosomal dominant diseases have a

male or female preponderance, e.g. I have never seen a female Marfans. I

was attributing it to imprinting but on reading about imprinting in detail

it cannot be the case.

3.We have been told that some tumours in the colon are associated with

microsatellite instability. What does this mean?

4.Can you explain why a patient with colorectal carcinoma might present with diarrhoea and abdominal pain?

5.What causes the blood to be altered in the presentation of melaena: is it intestinal juice?

6.What is the differential diagnosis of multiple rectal ulcers in an 18-yearold female?

7.What is the best surgical technique in a chronic (2-3 years) painful anal fissure that is located sagittally posteriorly?

8.Can I make a diagnosis of irritable bowel syndrome (IBS) in a 40-year-old

female patient without doing gastrointestinal investigations?

9.What is the cause of abdominal bloating, which is often a symptom in patients with irritable bowel syndrome (IBS)?

10.

1. Where is the Traub's area situated anatomically?

2. What does it mean if it is dull on percussion?

3. What is the proper way to percuss this area?