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An Antisense RNA Is an RNA That Base - Pairs with an mRNA and Prevents Its Translation One strategy to thwart the deleterious effects of

An Antisense RNA Is an RNA That Base-Pairs with an mRNA and Prevents Its Translation One strategy to thwart the deleterious effects of genes activated in disease states (such as cancer) is to generate antisense RNAs in affected cells. Suppose the transcription of a cancer-activated gene yielded an mRNA whose sequence included the segment 59-UACGGUCUAAGCUGA. Which of the following is the correct nucleotide sequence (59n39) for the template strand in a DNA duplex that would code for an antisense RNA? (Hint: Recall that the DNA strand that is not copied by RNA polymerase during transcription has a nucleotide sequence identical to that of the RNA being synthesized [except T residues are found in the DNA strand at sites where U residues occur in the RNA]).

a. 59- ATGCCAGATTCGACT

b. 59- TACGGTCTAAGCTGA

c. 59- TAGCGGTCTAAGCTGA

d. 59- TCAGCTTAGACCGCTA

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