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1 t 4 6 ( PDB ID ) imatinib ( drug name ) 1 . Download drug target structure and PDB using the Uniprot IDs

1t46(PDB ID) imatinib (drug name)
1. Download drug target structure and PDB using the Uniprot IDs and PDB ID s
2. Search for analogues(Top 10 molecules) for drug/bioactive molecules having within 85% structural similarity using pubchem or Zinc database 3D sdf format
3. Dock the 3D analogue structures of the Drug target also the bounded drug using either AutoDock/AutoDock vina
4. Tabulate the binding energy, No of hydrogen bonds, hydrophobic contacts, number of non-bonded contacts for top 5 molecules using LIGPLOT
5.a. Make figures with target binding site surface and docked ligand in ball and stick model using PyMOL.
b. Superimpose the top bounded molecule and drug bound molecule and find out the difference between the RMSD of both docked structures.
i need results in downloadable form for all of the following

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