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1) The following output is from a study described in Reisby et. al., (1977) that focused on relationship between plasma levels of a medication (imipramine)

1) The following output is from a study described in Reisby et. al., (1977) that focused on relationship between plasma levels of a medication (imipramine) and the clinical response in 66 depressed subjects (coded by ID). The primary outcome was the continuous Hamilton depression rating scale which was recorded on each subject twice during the baseline placebo week as well as at the end of each of the treatment weeks of the study.

Source

DF

Sum of Squares

F Value

Pr>F

Week

??

5913.537

61.86

<.0001

ID

??

7332.449

5.90

<.0001

Error

304

5812.34

Total

374

19334.67

What does the value 7332.449 represent in the above table?

2)The following output is from a study described in Reisby et. al., (1977) that focused on relationship between plasma levels of a medication (imipramine) and the clinical response in 66 depressed subjects (coded by ID). The primary outcome was the continuous Hamilton depression rating scale which was recorded on each subject twice during the baseline placebo week as well as at the end of each of the treatment weeks of the study.

Source

DF

Sum of Squares

F Value

Pr>F

Week

??

5913.537

61.86

<.0001

ID

??

7332.449

5.90

<.0001

Error

304

5812.34

Total

374

19334.67

If this study had been conducted on different individuals each week without any repeated measurements, how would the sum of squares in the above ANOVA table have changed? Be specific in your response.

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