1. The picture on the right shows a "patch-clamp", an instrument that is used to study the transport of ions/ molecules through cell-membrane pores. Assume that the diameter of the patch clamp pipette is 5onm, and that of the pore is snm. The partition coefficient of the species X+ in the membrane is 10 - and the membrane thickness is 3 nm. If the diffusivity of X-is 4 x 105 cm/s in both water and phospholipid, and its concentration of X+ within the cell is 12mM, and the concentration outside is 1 mm (a) Estimate the net transport rate (moles per unit time) of Xinto the pipette (assuming no voltage is applied, and disregarding the effect of membrane potential). [20 points) (b) What would lead to a greater increase in the rate calculated in part (a): increasing the partition coefficient 10 fold, or increasing the pore radius by a factor of 3 ? [20 points) Cool 1. The picture on the right shows a "patch-clamp", an instrument that is used to study the transport of ions/ molecules through cell-membrane pores. Assume that the diameter of the patch clamp pipette is 5onm, and that of the pore is snm. The partition coefficient of the species X+ in the membrane is 10 - and the membrane thickness is 3 nm. If the diffusivity of X-is 4 x 105 cm/s in both water and phospholipid, and its concentration of X+ within the cell is 12mM, and the concentration outside is 1 mm (a) Estimate the net transport rate (moles per unit time) of Xinto the pipette (assuming no voltage is applied, and disregarding the effect of membrane potential). [20 points) (b) What would lead to a greater increase in the rate calculated in part (a): increasing the partition coefficient 10 fold, or increasing the pore radius by a factor of 3 ? [20 points) Cool