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1 - What factors might be considered in determining the safety threshold of a drug's therapeutic index? 2 - What are some possible causes for

1 - What factors might be considered in determining the "safety threshold" of a drug's therapeutic index?

2 - What are some possible causes for drug interactions? Provide a pharmacokinetic example and a pharmacodynamic one.

3 - There remains considerable pressure on the FDA to shorten the drug approval process. What arguments support a speedier drug approval process? What argues against it? Use outside sources to answer this question.

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