194. A 62year old Female came with headache and toe pain which relieves with exposure to cold. On examination there is moderate splenomegaly. CBC revealed a Hb-11gm/dl and Platelet count of 1000*10%/microliter. The first line treatment in this patient would be a. Anagrelide b. Hydroxyurea c. Busulphan d. Ruxolitinib DAMS